Our company is the largest API manufacturer of LGD4033 Powder in China.Our production of LGD4033 has a history of 3 years, and all production LGD4033 raw materials have a purity of more than 99% and each batch has HPLC and NMR detection reports.The LGD4033 monthly output is 40kg and the quality is stable.
The LGD4033 powder produced by our company is mainly supplied to Canada and its European market, and the customer feedback is good. Our company is a leading supplier of health care products, research institutes and fitness enthusiasts.
The LGD4033 provided by our company is powder, the color is white , the standard package is 1 kg/aluminum foil bag.We also can be divided into smaller package for the customer.The order is unlimited.After customers purchase, they can be directly processed into tablets and liquids.
It would be the best choice to cooperate with us,due to we have below advantages.
1. Professional.We has developed and produced sram series for 5 years.Rich experience in production, stable product quality, product purity up to 99%.
2. Formal business.Our company can provide HPLC, nuclear magnetic and other professional detection map for each batch of products.
3. Fast delivery. Products will send out within 24hours,delivery time is 7-10days.
4. Good service. We will provide the most thoughtful service, from procurement, quality inspection, delivery to application, etc.
What is a lgd4033 powder
LGD4033 (Ligandrol), also known as Anabolicum, is the most powerful non-steroidal selective androgen receptor modulator (SARM) available on the market. Because high affinity and selectivity and androgen receptor, promote the anabolic activity of muscle, bone absorption and resistance of the anabolic activity, as well as the muscles and bones strong selectivity for prostate and sebaceous glands, it is welcomed by athletes. LGD - 4033 has experienced several recent research and and trials, has found the best and safest way to use lgd4033 is to achieve the steroid effect without steroid side effects.It is considered an excellent substitute for steroids: reducing body fat and increasing muscle mass. ind the best and safest way to use lgd4033 can achieve the effect of steroid without the side effects of steroid.It is considered an excellent substitute for steroids: reducing body fat and increasing muscle mass.
From a medical point of view, is studying with Ligandrol cure some disease, these diseases are associated with acute and chronic disease of muscle atrophy, age-related muscle loss, osteoporosis and cancer and other diseases.
LGD4033 Powder product information
LGD 4033 (Ligandrol)
Last updated Mar 28, 2018 25
Chemical Name: 4 – ((R) -2 – ((R) -2,2,2-trifluoro-1-hydroxyethyl) pyrrolidin-1-yl) -2-trifluoro-methyl) benzonitrile
Other Name(s): Ligandrol, LGD 4033, VK-5211, LGD, Anabolicum
Molecular Name: C14H12F6N2O
Half Life: 24 hours, depending on individual
LGD-4033, known also as Ligandrol and Anabolicum, is the strongest orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) currently on the market.
Popular with athletes, power lifters and body builders for its ability to both bulk and cut, Ligandrol produces steroid-like results without the side effects.
It’s considered an excellent supplement for those looking to recomp: reduce their body fat and increase lean muscle mass.
From a medical perspective, Ligandrol is being studied to treat conditions such as muscle wasting linked with acute and chronic diseases, age-related muscle loss, Osteoporosis and cancer.
Let’s take a closer look…
History Behind LGD 4033 Powder
LGD-4033 was originally discovered by Ligand pharmaceuticals and is currently under development by Viking Therapeutics as VK5211.
From the start, LGD-4033 has been anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.
How it Works LGD4033 Powder
Androgen receptors are selectively activated to promote the synthesis of metabolic activity in muscles and bones.Studies have shown that lgd-4033 has a high affinity for muscle and bone, not the prostate, liver or sebaceous glands, making it an ideal SARM for building and maintaining muscle mass and bone density.
Androgen (from the Greek "andro" means male humans) is a compound (natural or synthetic), with androgen receptors (special receptors on cells) to adjust vertebrates (including humans) the development and sustenance of male characteristics.Androgens are often steroid hormones.Selective androgen receptor modulators (SARM) are selective in their tissues.This means that it has a very high binding to androgen receptors.SARMS as "selective" can be entered by mouth, but only with a specific target area, in which case it can be combined with the male receptor in the muscle.
Clinical trials Since the initial discovery, two phases of clinical trials have been completed to study the use of lgd-4033 in muscle and bone growth.
Clinical trial stage 1: effects on weight loss and muscle strength.
The first phase of the clinical trial involved 76 healthy male adults, taking either placebo or 0.1mg, 0.3mg and 1.0mg LGD-4033 21 days.The study looked at the effects of ligand on weight loss, muscle strength, climbing ability and sex hormones, and the results were very good.
Clinical trial stage 2:
Viking Pharmaceuticals is currently conducting a second phase of clinical trials to verify that lgd-4033 can help individuals recover from hip fracture surgery.
It turns out that Ligandrol has the effect of reducing weight, improving muscle strength and enhancing bone density, which is beneficial for people with hip fractures caused by falls.
Since its initial discovery, two phases of clinical trials have been completed to study the application of LGD-4033 for muscle and bone growth.
The benefits of LGD4033 Powder
Seven main benefits were observed in the initial research and user feedback lgd-4033 evaluation:1.LGD-4033 increases muscle mass.The most direct benefit of supplementing Anabolicum is that it increases muscle mass without increasing fat.The first phase showed that participants who took 1.0mg Ligandrol increased their muscle mass by an average of 2.66 LBS (1.21kg) for 21 days.This increase is related to the dose, and we can speculate that more LGD-4033 will increase the muscle mass.(but you can't overdo it.)
2.LGD-4033 can improve strength and endurance.An important study was to measure participants' climbing speed and strength as indicators of muscle strength and endurance.The 21-day study showed that the speed and strength of the ladder was significantly improved by ingestion of LGD4033.It is reported that users found that by inging lgd -4033 during cycling, they also significantly increased muscle strength and endurance.
3.LGD-4033 selectively targets muscle and bone tissue.LGD4033 almost exclusively on muscle and bone tissue, which is why are studying how to use LGD4033 prevention and treatment of hip fractures, skeletal muscle to reduce disease, osteoporosis and recovery from hip fracture in the elderly.Studies have shown that, even if androgen activity is clearly present in muscle and bone tissue, if the correct Anabolicum dose is used, there is no significant change in psa.Preventing bone loss and increasing bone formation are two mechanisms to prevent osteoporosis.In addition to calcium and vitamin D, bisphosphonates can also be used in men and women.These drugs increase bone mineral density (BMD) by inhibiting osteoclast activity.
4.LGD-4033 May consume fat.LGD4033 has an amazing anti-decomposition activity, which means it can prevent muscle breakdown.This explains why some users gain muscle mass even when energy is low.By increasing muscle and bone, it indirectly reduces body fat, increases metabolic activity, and burns fat more easily.
5.LGD-4033 improves mental health.When you take LGD4033, many users will feel "positive, strong and alpha."This state of mental health and what some people call "aggression" may help them work harder at the gym and be more willing to compete with others.
6.LGD-4033 can help patients recover from hip fracture.The second phase of the Ligandrol clinical trial is currently underway.Viking pharmaceutical company noticed that older people risk of hip fracture is higher, because of the reduced muscle (muscle natural decline after the age of thirty years), hip fracture, and incidence of complications increase after the fall.LGD4033 can help increase bone density and increase muscle mass without the side effects of traditional treatments such as steroids.
7.LGD-4033 can treat muscle atrophy caused by cancer.A phase 1 clinical trial of Anabolicum showed that the results of building and maintaining muscle in healthy young men were good, prompting Viking Pharmaceuticals to study how LGD4033 was used to treat cancer-causing muscle atrophy.Trials are under way (2016).
Muscular dystrophy, including skeletal muscle loss, is a cancer-related symptom that begins early in the progression of cancer, affects the quality of life of the patient, and affects the ability to tolerate and survive chemotherapy.SARM increases muscle mass and improves body function in healthy and diseased individuals, and may provide new treatments for muscle atrophy and cancer cachexia.SARMs adjustment with androgen targeting the same synthetic metabolic pathways, but in the expected to have an impact on muscle mass and function dose range, has not yet been observed in the prostate, androgen effects of skin and hair.
The Side Effects of LGD4033 Powder
In the placebo controlled study, 76 healthy men (21-50 years old) were randomly assigned to either placebo or 0.1mg, 0.3mg, or 1.0mg LGD-4033,21 days.
LGD-4033 is well tolerated.There was no serious adverse event associated with the drug.The incidence of adverse events was similar between the activity group and the placebo group.At any given dose, hemoglobin, prostatic specific antigen, aspartate transaminase, alanine aminotransferase or QT interval did not significantly change.
The dosage of LGD-4033 was associated with dose-dependent inhibition of total testosterone, sex hormone binding globulin, high-density lipoprotein cholesterol and triglyceride levels.Only 1.0mg of follicle stimulating hormone and free testosterone showed significant inhibitory effects. The muscle mass was proportional to the dosage, but the amount of fat did not change significantly. The hormone levels and serum lipids were restored to baseline after withdrawal.
LGD-4033 is safe, it has good pharmacokerical features, and even in this short period of time the muscle mass increases, and the psa has not changed.
Like all supplements, the users of Ligandrol noticed some side effects during the study. It is worth noting, however, that the side effects of lgd-4033 seem to be not only trivial, but also improvable. The main clinical trial stage 1 showed that lgd-4033 had good tolerability and safety at all doses.
However, users also reported some side effects including headaches, hair growth and loss of nausea and fatigue.
The results and side effects vary from person to person, especially as a non-fda approved supplement as a minimum study.
No serious or sustained side effects were found in the LGD 4033 report. With the advent of a 24-hour half-life, everything you experience will quickly disappear. I also recommend that you limit each cycle to up to six weeks and reuse it after a month. Always pay attention to your body.
Does LGD-4033 cause temporary suppression of testosterone?
An interesting side effect of Ligandrol is a dose-dependent suppression of total testosterone and hormone-binding globulin levels. Although Ligandrol increased lean body mass, the study showed testosterone suppression from baseline to day 21 of the three-week study.
However, once LGD-4033 was discontinued, testosterone levels returned to their normal baseline by day 56. A mini-PCT (Post Cycle Therapy) should assist the body in returning to baseline.
Benefits have been documented with dosages as little as 3-10mg every 24 to 36 hrs. Research subjects have been know to tolerate therapy with notable benefits after 2 weeks with improvements continuing for up to 5 months (20 weeks). Note that research recognizes a increase in tolerance after 3 months with benefits continuing to decrease.
Many male users report the upper ideal limit for LGD to be 10mg per day in the morning for twelve weeks.
Although some women have reported using LGD-4033, it has been suggested that it may cause masculinisation lower doses are recommended. Females are advised to stick to an upper limit of 5mg per day.
LGD4033 Powder Dosing Guidelines
For Bulking: A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by at least 10 lbs.
For Cutting: Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks.
For Recomping: LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks.
In the studies done on Ligandrol they are using sometimes as little as 1mg and still seeing pronounced muscle gain. This randomized, double-blind study showed that it was safe even up to 22 mg per day for average people.
Post Cycle Therapy (PCT)
Post Cycle Therapy (PCT) is required when taking SARMS to help preserve muscle gains, prevent fat accumulation, maintain mood and motivation, and retain strength in muscles. Cycling also helps to allow hormone levels to return to their natural state in order to prevent unwanted dependency.
Typically, a PCT will last the same duration as supplementation. So if a user supplemented with a hormone for 12 weeks, a PCT of 12 weeks would also be required to bring their hormones back to baseline.
But do I need a PCT when taking SARMs?
Typically, SARMs do not disrupt hormone levels in the body, which means that a traditional PCT is not necessary. However, studies and user reviews show that LGD-4033 temporarily decreases testosterone levels. These levels are quickly reversed when supplementation is stopped, and a mini PCT can help speed up the recover process.
LGD-4033 can be easily and legally purchased online for research purposes, which means there are ample companies to choose from. However, as the compound is yet to be approved for human consumption, the SARM industry is unregulated and it’s important to do your due diligence in finding a reputable supplier.
Final comment: our view of LGD4033.
As the most powerful SARM in the market, and renowned in the bodybuilding industry, lgd-4033 is considered one of the best supplements to build muscle without steroid side effects.
Due to its anti catabolism and anabolism activity, Ligandrol is very suitable for repeated use, which makes it become a prominent supplements in your strong and handsome toolkit, it combines with other SARM very well.
Compared with other SARM, LGD4033 is most prominent in the level of human clinical research.Although it has not yet been approved for use in humans, the trials are still being studied, but in some studies it has been shown to increase the amount of lean muscle in humans rather than mice or primates.
In addition, these trials showed encouraging results in just three weeks, and the users were said to have achieved good results after the 12-week cycle.
Because it selectively targets muscle and bone tissue, lgd-4033 does not have the side effects of steroid use.
The only obvious worry for Ligandrol is that the dose is suppressed by testosterone.However, once the circulation and PCT are completed, the normal testosterone level can be quickly restored.
If you are looking for increased muscle endurance, body mass and reduced fat, and no side effects of testosterone, lgd-4033 is the ideal choice for your next supplement.
Is Ligandrol (LGD4033) valid?
LGD is developed to treat muscular dystrophy, such as aging, osteoporosis, muscular dystrophy and cancer.